Repetitivity and therapy of luteinized unruptured follicle syndrome

Document Type

Book Chapter


Obstetrics and Gynaecology (East Africa)


At laparoscopy performed in the early luteal phase the presence of a corpus luteum with or without ovulation stigma was evaluated in 24 women. At the same time the progesterone concentration in peritoneal fluid and serum was determined. Women (20/24) without ovulation stigma and with low peritoneal progesterone concentration, were considered to have a luteinized unruptured follicle syndrome (LUF syndrome). In 24 women an ambulatory puncture of the pouch of Douglas was performed at the same time in the next cycle. Almost all women (19/ 20) without ovulation stigma and low peritoneal fluid progesterone concentration, again showed a low progesterone concentration in peritoneal fluid, suggesting the continuancy of the LUF syndrome. Fifteen patients were stimulated with human menopausal gonadotropins (hMG), twelve of which also received human chorionic gonadotropins (hCG). In the latter group eleven had a high peritoneal progesterone concentration as established by another ambulatory puncture. One remained low, as did those (3/15) in whom hCG was withheld due to the occurrence of an endogenous LH peak. The results suggest that the LUF syndrome ean be repeated in at least two eonseeutive cydes, and that stimulation with hMG and hCG could be therapeutic, three pregnancies occurred, all in this group.


This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

Ovulation and its Disorders