Pregabalin for Treatment of Docetaxel-Related Hand-Foot Syndrome

Document Type



Internal Medicine (East Africa)


Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysesthesia, is a painful, often debilitating condition related to the use of various chemotherapies. HFS usually presents with erythema, edema, and a burning sensation of the palmoplantar surfaces. The pathophysiology of HFS is not fully understood, and hence treatment options can often be challenging. We describe the case of patient with HFS due to docetaxel use, presenting with extreme hand and feet pain resulting in inability to walk. Use of pregabalin resulted in significant improvement in his symptoms, including his ability to bear weight and walk, with limited side effects.

Publication (Name of Journal)

Journal of Pain and Symptom Management