ln-111 labeled monoclonal anti-carcinoembryonic antigen antibody (ZCE025) in the immunoscintigraphlc imaging of metastatic antigen-producing adenocarcinomas

Authors

Mansoor Saleh, Aga Khan UniversityFollow
Richard Wheeler, University Of Alabama At Birmingham, USA
Lee Jeannette, University Of Alabama At Birmingham, USA
M Khazaeli, University Of Alabama At Birmingham, USA
Michael Unger, University Of Alabama At Birmingham, USA
Charles Russell, University Of Alabama At Birmingham, USA
Albert LoBuglio, University Of Alabama At Birmingham, USA

Document Type

Article

Department

Haematology and Oncology, East Africa

Abstract

The carcinoembryonic antigen (CEA) is a clinically useful marker since it is expressed by adenocarcinomas of diverse origin. Detection and quantitation of circulating CEA levels is used to follow the clinical course of metastatic adenocarcinoma. In this phase I study, the toxicity, pharmacokinetics, and optimal imaging dose of an ln-111 labeled monoclonal anti-CEA antibody (ZCE025) was studied in patients with colorectal carcinoma or any CEA-producing tumor. Twenty-four of 26 evaluable patients (92%) demonstrated at least one site of tumorspecific antibody uptake. Sixty-seven sites of metastatic cancer were identified by conventional diagnostic studies. Twenty-nine (43%) of these sites were demonstrable by radioimmune imaging using ZCE025. Twenty-five additional sites of antibody uptake were observed but could not be associated with metastatic deposits. Lymph node and visceral metastases were visualized more frequently than bone, subcutaneous, lung, or liver metastases. Neither tumor size nor antibody dose (2.5-40 mg) appeared to influence the frequency of tumor imaging. The pharmacokinetics of the ln-111 labeled antibody fitted a two-compartment model, and patients receiving < 10 mg of antibody showed a faster clearance of the antibody than those who received > 10 mg.

Comments

This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

Clinical nuclear medicine

Recommended Citation

Saleh, M., Wheeler, R., Jeannette, L., Khazaeli, M., Unger, M., Russell, C., LoBuglio, A. (1991). ln-111 labeled monoclonal anti-carcinoembryonic antigen antibody (ZCE025) in the immunoscintigraphlc imaging of metastatic antigen-producing adenocarcinomas. Clinical nuclear medicine, 16(2), 110-116.
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_haematol_oncol/155