Phase I trial of the chimeric anti-GD2 monoclonal antibody ch14.18 in patients with malignant melanoma
Document Type
Article
Department
Haematology and Oncology, East Africa
Abstract
The chimeric monoclonal anti-GD2 antibody ch14.18 is made up of the variable region of the murine anti-GD2 antibody 14.18 (or its IgG2a switch variant 14G2a) and the constant region of human IgG1k. Ch14.18 mediates antibody dependent cytoxicity and complement dependent lysis in vitro. In a phase 1 trial, 13 patients with metastatic melanoma received ch14.18 as a single dose of 5–100 mg. Therapy was associated with an infusion-related abdominal/pelvic pain syndrome, which required intravenous morphine for control. The pharmacokinetics of ch14.18 best fit a two-compartment model with a T1/2α of 24±1 hr and a T1/2β of 181±73 hr. Eight of 13 patients developed a weak-modest antibody response directed at the variable region of ch14.18. Clinical antitumor responses were not observed at the doses employed in this study. However, patients receiving >45 mg of ch14.18 had antibody detectable on tumor cells analyzed by fluorescent activated cell sorter. Further modification of the therapeutic regime employing larger doses and frequent administration of ch14.18 are planned.
Publication (Name of Journal)
Human Antibodies
DOI
https://doi.org/10.3233/HAB-1992-3104
Recommended Citation
Saleh, M.,
B, K. M.,
Richard, W.,
Laquetta, A.,
Arabella, T.,
William, G.,
Ralph, R.,
Alice, Y.,
Stephen, G.
(1992). Phase I trial of the chimeric anti-GD2 monoclonal antibody ch14.18 in patients with malignant melanoma. Human Antibodies, 3(1), 19-24.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_haematol_oncol/140
Comments
This work was published before the author joined Aga Khan University.