Hematopoietic effect of the aqueous calyx extract of Hibiscus sabdariffa in rats (LB549)

Document Type

Article

Department

Biomedical Sciences (East Africa)

Abstract

Cyclophosphamide, a widely-used immunosuppressive agent, may adversely affect the bone marrow. This study investigated the hematopoietic effect of the aqueous calyx extract of Hibiscus sabdariffa (HS) in cyclophosphamide-induced anaemic rats. H. sabdariffa (HS) is used locally as a hematinic concoction supposedly to raise blood level. 50g of pulverized HS leaves were boiled in 500ml distilled water and the filterate air-dried at 400C. Wistar rats (n = 24) treated as approved by Lagos State University College of Medicine Experimental Animal Ethics Committee, were grouped into 4: Control - water ad libitum; Group I- 200mg/Kg/day HS Extract; GP II 30mg/kg/day Cyclophosphamide for 5 days and Group III – HS 200mg/Kg/day for 30 days + 30mg/kg/day Cyclophosphamide for 5 days. Blood sample was collected directly from the heart chambers of the rats after a light anaesthesia with diethyl ether. In Group I, HS extract caused increase in Hb, PCV, RBC, platelet (PLT) count, MCV, and MCH (p0.05). The results from this study suggest a hematopoietic potential for the aqueous leaf extract of H. sabdariffa.

Comments

This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

Federation of American Societies for Experimental Biology

DOI

https://doi.org/10.1096/fasebj.28.1_supplement.lb549

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