Nephroprotective effects of the aqueous root extract of harungana madagascariensis(L)
Document Type
Article
Department
Biomedical Sciences (East Africa)
Abstract
In African traditional medicine, decoctions from different parts of Harungana madagascariensis (L.) are highly valued in the treatment of various human diseases including drug related renal disease. In the current study, effects of pretreatments with single daily oral 100–500 mg/kg/day of the root aqueous extract of Harungana madagascariensis were investigated in acute and repeated dose acetaminophen nephrotoxic rats for 24 hours and 14 days, respectively, using renal function parameters–serum urea (UR), uric acid (UA) and creatinine (CR). Effects of the extract pretreatments on the hematological and renal histological profile in acetaminophen nephrotoxic rats were also evaluated. Results showed that treatment with intraperitoneal acetaminophen for 24 hours and 14 days induced significant (p< 0.05, p< 0.01, p< 0.001) elevations in the serum concentrations of UR, UA and CR, varying degrees of tubular necrosis on histology and varying degrees of alterations in the hematological parameters in acute and repeated dose acetaminophen nephrotoxic rats, respectively. However, pretreatments with graded oral doses of the extract significantly (p< 0.05, p< 0.01, p< 0.001) attenuated elevations in the serum concentrations of UR, UA and CR, and improved diffuse tubular necrosis in both models of acetaminophen nephrotoxicity. The extract also significantly (p< 0.05, p< 0.01, p< 0.001) improved packed cell volume (PCV), hemoglobin (Hb), and total leucocyte count (TLC) levels but non-significant (p> 0.05) increase in the mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration
Publication (Name of Journal)
International journal of applied research in natural products
Recommended Citation
A, A. A.,
A, O. J.,
S, B. A.,
Elias, S.,
O, A. A.,
O, I. B.,
O, O. M.,
O, I. E.,
B, B. O.,
O, O. O.,
O, A. E.
(2008). Nephroprotective effects of the aqueous root extract of harungana madagascariensis(L). International journal of applied research in natural products, 1(1), 6-14.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_biomed/19
Comments
This work was published before the author joined Aga Khan University.