Protective activities of the aqueous root extract of Harungana madagascariensis in acute and repeated acetaminophen hepatotoxic rats
Document Type
Article
Department
Biomedical Sciences (East Africa)
Abstract
In this study, the protective effects of 100 – 500 mg/kg/day of the aqueous root extract of Harungana madagascariensis Lam. ex Poir were evaluated on the average body weight, relative liver-body weight, serum alanine (ALT) and aspartate aminotransferases (AST), alkaline phosphatase (ALP), total (TB) and conjugated bilirubin (CB), triglycerides (TG), total cholesterol (TC), cholesterol fractions (HDL-c, LDL-c, VLDL-c), fasting blood glucose (FBG), total protein (TP) and albumin (ALB) in the acute and repeated dose acetaminophen hepatotoxic rats. Results showed that acute intraperitoneal injection of 800 mg/kg of acetaminophen induced significant (p<0.001) elevations in the serum concentrations of ALT, AST, ALP and FBG but caused significant (p<0.001) decreases in the serum concentrations of TP and ALB, while inducing non-significant (p>0.05) alterations in the serum levels of lipids, TB and CB. However, pretreatments with 100 - 500 mg/kg of Harungana madagascariensis significantly (p<0.05, p<0.01, p<0.001) attenuated elevations of ALT, AST, ALP and FBG. In addition, the extract significantly (p<0.05, p<0.01, p<0.001) attenuated reduction in the serum levels of TP and ALB while inducing non-significant (p>0.05) alterations in the serum lipids. Repeated acetaminophen hepatotoxicity caused similar effects in the measured parameters except that it was associated with significant (p<0.001) reduction in the FBG while inducing significant (p<0.05, p<0.001) increases in the serum TB and CB. Oral pretreatments with the extract significantly (p<0.001) enhanced acetaminophen induced hypoglycemia while significantly (p<0.05, p<0.01) attenuating significant elevations in the serum levels of TB and CB, in dose related fashion. The associated histopathologic features of moderate-to-severe hepatic necrosis were also attenuated by the extract. Thus, the overall results of this study confirm the folkloric use of the extract in the treatment of drug-induced hepatotoxicity.
Publication (Name of Journal)
International Journal of Applied Research in Natural Products
DOI
https://doi.org/10.1055/s-0028-1084157
Recommended Citation
Adeneye, A. A.,
Olagunju, J. A.,
Elias, S.,
Olatunbosun, O. D.,
Mustafa, A. O.,
Adeshile, O. I.,
Ashaolu, A. O.,
Laoye, T. A.,
Bamigboye, A. O.,
Adeoye, A. O.
(2008). Protective activities of the aqueous root extract of Harungana madagascariensis in acute and repeated acetaminophen hepatotoxic rats. International Journal of Applied Research in Natural Products, 1(3), 29-42.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_biomed/13
Comments
This work was published before the author joined Aga Khan University.