Intrahepatic cholestasis of pregnancy: Case series of a rare disease in an African setting

Authors

Davis Rubagumya, Aga Khan University, Tanzania
Miriam Mgonja, Aga Khan UniversityFollow
Munawar Kaguta, Aga Khan Hospital, Tanzania
Ahmed Jusabani, Aga Khan UniversityFollow
Muzdalfat Abeid, Aga Khan University,TanzaniaFollow
Nancy Matillya, Aga Khan UniversityFollow

Document Type

Case Report

Department

Imaging and Diagnostic Radiology (East Africa)

Abstract

Intrahepatic cholestasis of pregnancy commonly presents in the second and third trimester with unexplained pruritus sine materia, abnormal liver function tests, and/or elevated serum total bile acid concentration. Its incidence ranges from less than 1% to 27.6%, with Araucana Indians from Chile being the highest affected. Intrahepatic cholestasis of pregnancy complicates pregnancy, hence influencing its outcomes. Our series involves three cases of pruritus in pregnancy ending with one elective cesarean delivery and two emergency cesarean deliveries without any significant complications to babies as well as immediate resolution of maternal symptoms. High index of suspicion for intrahepatic cholestasis of pregnancy is of paramount importance among clinicians even in primary care setup. Prompt treatment and intervention will prevent poor perinatal outcome.

Comments

This work was published - the author joined Aga Khan University.

Publication (Name of Journal)

SAGE Open Medical Case Reports

Recommended Citation

Rubagumya, D., Mgonja, M., Kaguta, M., Jusabani, A., Abeid, M., & Matillya, N. (2022). Intrahepatic cholestasis of pregnancy: Case series of a rare disease in an African setting. SAGE Open Medical Case Reports, 10, 2050313X221105832.