Title

Characteristics and classification of high-grade B-cell lymphomas in resource-limited settings

Document Type

Article

Department

Pathology (East Africa)

Abstract

The aim of this study is to confirm the guild line of pathological diagnosis of BMFS.

Materials and method:

The registered 1000 cases of Japanese Pediatric MDS/AA central review system were reviewed by board members and used in this study. Bone marrow biopsy and clot materials of paraffin sections were used for immunohistochemistry (IHC).

Results:

Aplastic anemia cases showed very severe hypoplastic marrow without megakaryocyte and scarce granulopoiesis. Lymphocytes, especially CD8 þ T-cells, were predominant. RCC cases were hypoplastic marrow with patchy pattern. Ery- thropoiesis were mainly composed by large erythroblasts with left shift and baring hemoglobin fetal type (HbF). A few marrow cells were stained p53. Megakaryocytes with single small nuclei or micromegakaryocytes were demonstrated by IHC. RCMD was hypo-normocellular marrow and distinctive erythropoiesis with left shift. P53 þ cells were relatively more than RCC. RAEB or AML with MRC had increased number of p53 þ cells and CD34 þ blasts. Small and micromegakaryocytes were frequently observed. No evidence of AA or MDS cases were categorized into secondary dyshematopoiesis of unknown causes or inherited BMFS.

Conclusion: Bone marrow pathology with IHC were useful for the definite diagnosis of childhood BMFS.

Comments

This work was published before the author joined Aga Khan University.

Publication

Pathology

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