Characteristics and classification of high-grade B-cell lymphomas in resource-limited settings
Document Type
Article
Department
Pathology (East Africa)
Abstract
The aim of this study is to confirm the guild line of pathological diagnosis of BMFS.
Materials and method:
The registered 1000 cases of Japanese Pediatric MDS/AA central review system were reviewed by board members and used in this study. Bone marrow biopsy and clot materials of paraffin sections were used for immunohistochemistry (IHC).
Results:
Aplastic anemia cases showed very severe hypoplastic marrow without megakaryocyte and scarce granulopoiesis. Lymphocytes, especially CD8 þ T-cells, were predominant. RCC cases were hypoplastic marrow with patchy pattern. Ery- thropoiesis were mainly composed by large erythroblasts with left shift and baring hemoglobin fetal type (HbF). A few marrow cells were stained p53. Megakaryocytes with single small nuclei or micromegakaryocytes were demonstrated by IHC. RCMD was hypo-normocellular marrow and distinctive erythropoiesis with left shift. P53 þ cells were relatively more than RCC. RAEB or AML with MRC had increased number of p53 þ cells and CD34 þ blasts. Small and micromegakaryocytes were frequently observed. No evidence of AA or MDS cases were categorized into secondary dyshematopoiesis of unknown causes or inherited BMFS.
Conclusion: Bone marrow pathology with IHC were useful for the definite diagnosis of childhood BMFS.
Publication ( Name of Journal)
Pathology
Recommended Citation
Sayed, S., Kovach, A. E., McLaughlin, P., Moloo, Z., Busarla, S. V. P., Sherman, O., ... & Sohani, A. R. (2014). Characteristics and classification of high-grade B-cell lymphomas in resource-limited settings. Pathology, 46, S99.
Comments
This work was published before the author joined Aga Khan University.