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Submissions from 2015

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Co-targeting of cyclooxygenase-2 and foxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells, Maqbool Ahmed, Azhar Hussain, Abdul K. Siraj, Shahab Uddin, Nasser Al-Sanea, Fouad Al-Dayel, Mohammed Al-Assiri, Shaham Beg, and Khawla S. Al-Kuraya

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Dual targeting of mTOR activity with Torin2 potentiates anticancer effects of cisplatin in epithelial ovarian cancer, Azhar Hussain, Maha Al-Romaizan, Maqbool Ahmed, Saravanan Thangavel, Fouad Al-Dayel, Shaham Beg, Shahab Uddin, Abdul K Siraj, and Khawla S Al-Kuraya

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Role of x-linked inhibitor of apoptosis as a prognostic marker and therapeutic target in papillary thyroid carcinoma, Azhar Hussain, Rong Bu, Maqbool Ahmed, Zeenath Jehan, Shaham Beg, Saif Al-Sobhi, Fouad Al-Dayel, Abdul K. Siraj, Shahab Uddin, and Khawla S. Al-Kuraya

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ALK alteration is a frequent event in aggressive breast cancers, Abdul K. Siraj, Shaham Beg, Zeenath Jehan, Sarita Prabhakaran, Maqbool Ahmed, Azhar Hussain, Fouad Al-Dayel, Asma Tulbah, Dahish Ajarim, and Khawla S. Al-Kuraya

Submissions from 2014

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High prevalence of mTOR complex activity can be targeted using torin2 in papillary thyroid carcinoma, Maqbool Ahmed, Azhar Hussain, Prashant Bavi, Saeeda O. Ahmed, Saif S. Al Sobhi, Fouad Al-Dayel, Shahab Uddin, and Khawla S. Al-Kuraya

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Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis, Shahab Uddin, Azhar Hussain, Omar S. Khan, and Khawla S. Al-Kuraya

Submissions from 2013

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Bortezomib inhibits proteasomal degradation of IκBα and induces mitochondrial dependent apoptosis in activated B-cell diffuse large B-cell lymphoma, Rong Bu, Azhar Hussain, KA Al-Obaisi, M Ahmed, Shahabuddin, and KS Al-Kuraya

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Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release, Azhar Hussain, Shahab Uddin, Maqbool Ahmed, Fouad Al-Dayel, Prashant P. Bavi, and Khawla S. Al-Kuraya

Submissions from 2012

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FoxM1 and its association with matrix metalloproteinases (MMPs) signaling pathway in papillary thyroid carcinoma, Maqbool Ahmed, Shahabuddin, Azhar Hussain, Aisha Alyan, Zeenath Jehan, Fouad Al-Dayel, Abdulrehman Al-Nuaim, Saif Al-Sobhi, Tarek Amin, Prashant Bavi, and Khawla S. Al-Kuraya

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c-Met inhibitor synergizes with tumor necrosis factor-related apoptosis-induced ligand to induce papillary thyroid carcinoma cell death, Rong Bu, Shahabuddin, Maqbool Ahmed, Azhar Hussain, Saif Alsobhi, Tarek Amin, Abdurahman Al-Nuaim, Fouad Al-Dayel, Jehad Abubaker, Prashant Bavi, and Khawla S Al-Kuraya

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Cross-talk between NFkB and the PI3-Kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis, Azhar Hussain, Saeeda O. Ahmed, Maqbool Ahmed, Omar S. Khan, Sally Al Abdul Mohsen, Leonidas C. Platanias, Khawla S. Al-Kuraya, and Shahab Uddin

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Over-expression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma, Shahabuddin, Azhar Hussain, Maqbool Ahmed, Khawar Siddiqui, Fouad Al-Dayel, Prashant Bavi, and Khawla S. Al-Kuraya

Submissions from 2011

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Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma, Prashant Bavi, Shahabuddin, Maqbool Ahmed, Zeenath Jehan, Rong Bu, Jehad Abubaker, Mehar Sultana, Nasser Al-Sanea, Alaa Abduljabbar, Luai H. Ashari, Samar Alhomoud, Fouad Al-Dayel, Sarita Prabhakaran, Azhar Hussain, and Khawla S. Al-Kuraya

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The biological and clinical impact of inhibition of NF- ĸB initiated apoptosis in diffuse large B-cell lymphoma (DLBCL), Prashant Bavi, Shahabuddin, Rong Bu, Maqbool Ahmed, Jehad Abubaker, Valorie Balde, Zeeshan Qadri, Dahish Ajarim, Fouad Al-Dayel, Azhar Hussain, and Khawla S Al-Kuraya

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HGF/c-met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma, Rong Bu, Shahabuddin, Prashant Bavi, Azhar Hussain, Fouad Al-Daye, Samir Ghourab, Maqbool Ahmed, and Khawla S Al-Kuraya

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Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma, Azhar Hussain, Maqbool Ahmed, Saeeda Ahmed, Pulicat Manogaran, Leonidas C. Platanias, Syed N. Alvi, Khawla S. Al-Kuraya, and Shahauddin

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Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines, Azhar Hussain, Shahabuddin, Rong Bu, Omar S. Khan, Saeeda O. Ahmed, Maqbool Ahmed, and Khawla S. Al-Kuraya

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Genome wide expression analysis of Middle Eastern colorectal cancer reveals FoxM1 as a novel target for cancer therapy, Shahabuddin, Maqbool Ahmed, Azhar Hussain, Jehad Abubaker, Nasser Al-Sanea, Alaa Abdul Jabbar, Luai H. Ashari, Samar Alhomoud, Fouad Al-Dayel, Zeenath Jehan, Prashant Bavi, Abdul K Siraj, and Khawla S. Al-Kuraya

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Coexpression of activated c-met and death receptor 5 predicts better survival in colorectal carcinoma, Shahabuddin, Azhar Hussain, Maqbool Ahmed, Nasser Al-Sanea, Alaa Abduljabbar, Luai H. Ashari, Samar Alhomoud, Fouad Al-Dayel, Prashant Bavi, and Khawla S. Al-Kuraya

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Role of leptin and its receptors in the pathogenesis of thyroid cancer, Shahabuddin, Azhar Hussain, Abdul K Siraj, Omar S Khan, Prashant P Bavi, and Khawla S Al-Kuraya

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Over expression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and its inhibition potentiates cisplatin induced apoptosis, Shahabuddin, Zeenath Jehan, Maqbool Ahmed, Aisha Alyan, Fouad Al-Dayel, Azhar Hussain, Prashant Bavi, and Khawla S Al-Kuraya

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Demethylation of TMS1 gene sensitizes thyroid cancer cells to trail-induced apoptosis, Abdul K. Siraj, Azhar Hussain, Maha Al-Rasheed, Maqbool Ahmed, Prashant Bavi, Saif Al-Deen Sulimani Alsobhi, Abdurahman Al-Nuaim, Shahabuddin, and Khawla Al-Kuraya

Submissions from 2010

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Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations, Prashant Bavi, Sarita E Prabhakaran, Jehad Abubaker, Zeeshan Qadri, Thara George, Nasser Al-Sanea, Alaa Abduljabbar, Luai H Ashari, Samar Alhomoud, Fouad Al-Dayel, Azhar Hussain, Shahabuddin, and Khawla S Al-Kuraya

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Apigenin induces apoptosis via downregulation of S-phase kinase-associated protein 2-mediated induction of p27Kip1 in primary effusion lymphoma cells, Azhar Hussain, AS Khan, SO Ahmed, M Ahmed, LC Platanias, Khawla S Al-Kuraya, and Shahbuddin

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Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling, Azhar Hussain, Shahabuddin, Maqbool Ahmed, Rong Bu, Saeeda O. Ahmed, Jehad Abubaker, Mehar Sultana, Dahish Ajarim, Fouad Al-Dayel, Prashant Bavi, and Khawla S Al-Kuraya

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Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer, Shahabuddin, Maqbool Ahmed, Azhar Hussain, Lina Assad, Fouad Al-Dayel, Prashant Bavi, Khawla S. Al-Kuraya, and Adnan Munkarah

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Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma, Shahabuddin, Prashant Bavi, Abdul K Siraj, Maqbool Ahmed, Maha Al-Rasheed, Azhar Hussain, Mohammed Ahmed, Tarek Amin, Ali Alzahrani, Fouad Al-Dayel, Jehad Abubaker, Rong Bu, and Khawla S Al-Kuraya

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Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma, Shahabuddin, Rong Bu, Maqbool Ahmed, Azhar Hussain, Dahish Ajarim, Fouad Al-Dayel, Prashant Bavi, and Khawla S Al-Kuraya

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Inhibition of c-MET is a potential therapeutic strategy for treatment of diffuse large B-cell lymphoma, Shahabuddin, Azhar Hussain, Maqbool Ahmed, Fouad Al-Dayel, Rong Bu, Prashant Bavi, and Khawla S Al-Kuraya

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Inhibition of fatty acid synthase suppresses c-Met receptor kinase and induces apoptosis in diffuse large B-cell lymphoma, Shahabuddin, Azhar Hussain, Maqbool Ahmed, Rong Bu, Saeeda O. Ahmed, Dahish Ajarim, Fouad Al-Dayel, Prashant Bavi, and Khawla S. Al-Kuraya

Submissions from 2009

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Proteasome inhibitor MG-132 mediated expression of p27Kip1 via S-phase kinase protein 2 degradation induces cell cycle coupled apoptosis in primary effusion lymphoma cells, Azhar Hussain, Maqbool Ahmed, Saeeda O Ahmed, Sara Al-Thari, Asma s Khan, Shirin Razack, Leonidas Platanias, Khawla S Al-Kuraya, and Shahabuddin

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Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer, Zeenath Jehan, Prashant Bavi, Mehar Sultana, Jehad Abubaker, Rong Bu, Azhar Hussain, Ghazi Alsbeih, Nasser Al-Sanea, Alaa Abduljabbar, Luai H. Ashari, Samar Alhomoud, Fouad Al-Dayel, Shahabuddin, and Khawla S Al-Kuraya

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Bortezomib-mediated expression of p27Kip1 through S-phase kinase protein 2 degradation in epithelial ovarian cancer, Shahabuddin, Maqbool Ahmed, Azhar Hussain, Zeenath Jehan, Fouad Al-Dayel, Adnan Munkarah, Prashant Bavi, and Khawla S Al-Kuraya

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Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication, Shahabuddin, Prashant Bavi, Azhar Hussain, Ghazi Alsbeih, Nasser Al-Sanea, Alaa Abdul Jabbar, Luai H. Ashari, Samar Alhomoud, Fouad Al-Dayel, Maqbool Ahmed, and Khawla S. Al-Kuraya

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High prevalence of fatty acid synthase expression in colorectal cancers in middle eastern patients and its potential role as a therapeutic target, Shahab Uddin, Azhar Hussain, Maqbool Ahmed, Jehad Abubaker, Nasser Al-Sanea, Alaa AbdulJabbar, Luai H. Ashari, Samar Alhomoud, Fouad Al-Dayel, Prashant Bavi, and Khawla S. Al-Kuraya

Submissions from 2008

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Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma, Prashant Bavi, Jehad Abubaker, Azhar Hussain, Meher Sultana, Fouad Al-Dayel, Shahab Uddin, and Khawla S. Al-Kuraya

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Curcumin suppresses constitutive activation of NFKB and requires functional bax to induce apoptosis in burkitt’s lymphoma cell lines., Azhar Hussain, Maqbool Ahmed, Naif A Al-Jomah, Asma S Khan, Subramanian Manogaran Pulicat, Mehar Sultana, Jehad Abubaker, Leonidas C Platanias, Khawla S Al-Kuraya, and Shahab Uddin

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Distinct gene expression profiles: nodal versus extranodal diffuse large B-cell lymphoma, Z Jehan, A.K Siraj, J Abubaker, C Ruiz, R Simon, M Sultana, S Uddin, P Bavi, Azhar Hussain, S Razack, A Ezzat, F Al-Dayel, G Sauter, and K.S Al-Kuraya

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Bortezomib (velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer, Shahab Uddin, Maqbool Ahmed, Prashant Bavi, Raafat El-Sayed, Nasser Al-Sanea, Alaa AbdulJabbar, Luai H. Ashari, Samar Alhomoud, Fouad Al-Dayel, Azhar Hussain, and Khawla S. Al-Kuraya

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Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers, Shahab Uddin, Abdul K. Siraj, Maha Al-Rasheed, Maqbool Ahmed, Rong Bu, Jeffrey N. Myers, Abdulrahman Al-Nuaim, Saif Al-Sobhi, Fouad Al-Dayel, Prashant Bavi, Azhar Hussain, and Khawla S. Al-Kuraya

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S-phase kinase protein 2 is an attractive therapeutic target in a subset of diffuse large B-cell lymphoma, S Uddin, Azhar Hussain, M Ahmed, A Belgaumi, F Al-Dayel, D Ajarim, P Bavi, and KS Al-Kuraya

Submissions from 2007

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Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells, Azhar Hussain, Naif A. Al-Jomah, Abdul K. Siraj, Pulicat Manogaran, Khalid Al-Hussein, Jehad Abubaker, Leonidas C. Platanias, Khawla S. Al-Kuraya, and Shahab Uddin

Submissions from 2006

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Curcumin induces apoptosis via inhibition of PI3′-kinase/AKT pathway in acute T cell leukemias, Azhar Hussain, M. Al-Rasheed, P. S. Manogaran, K. A. Al-Hussein, L.C. Platanias, K. Al Kuraya, and S. Uddin

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PI3’/AKT pathway plays a critical role in the survival of DLBCL, S Uddin, Azhar Hussain, PS Manogaran, AK Siraj, N Al-Jomah, VL Atizado, A Moorji, H El-Solh, P Bavi, and K Al-Kuraya

Submissions from 2005

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Childhood and adult ALL a: differences in epigenetic lesions associated with cell cycle genes, Marina I. Gutiérre, Abdul K. Siraj, Muna M. Ibrahim, Azhar Hussain, and Kishor Bhatia

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Inhibition of phosphatidylinositol 3’-kinase/AKT –signaling promotes apoptosis of primary effusion lymphoma cells, Shahab Uddin, Azhar Hussain, Khaled A. Al-Hussein, Pulicat S. Manogaran, Amitha Wickrema, Marina I. Gutierrez, and Kishor G. Bhatia

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Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma, Shahab Uddin, Azhar Hussain, Pulicat S. Manogaran, Khaled Al-Hussein, Leonidas C. Platanias, Marina I. Gutierrez, and Kishor G. Bhatia

Submissions from 2004

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Differences in the expression of apoptotic proteins in burkitt's lymphoma cell lines: potential models for screening apoptosis-inducing agents, Jean-Pierre Doucet, Azhar Hussain, Maha Al-Rasheed, Gianluca Gaidano, Marina I Gutiérrez, Ian Magrath, and Kishor Bhatia

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Immature B cell malignancies synthesize VEGF, VEGFR-1 (Flt-1) and VEGFR-2 (KDR), Adila El-Obeid, Nadia Sunnuqrut, Azhar Hussain, Khalid Al-Hussein, Marina I Gutiérrez, and Kishor Bhatia

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Frequent silencing of fragile histidine triad gene (FHIT) in burkitt’s lymphoma is associated with abberent hypermethylation, Azhar Hussain; Marina I. Gutiérrez; Georgina Timson; Abdul K. Siraj; Clara Deambrogi; Maha Al-Rasheed,; Gianluca Gaidano; Ian Magrath; and Kishor Bhatia

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Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway, Shahab Uddin, Azhar Hussain, Khaled Al-Hussein, Leonidas C. Platanias, and Kishor GBhatia

Submissions from 2003

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The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid cells, Kishor Bhatia, Abdul K Siraj, Azhar Hussain, Rong Bu, and Marina I Gutiérrez

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas apoptosis in burkitt's lymphomas with loss of multiple pro-apoptotic proteins, Azhar Hussain, JP Doucet, M Gutierrez, M Ahmad, K Al-Hussein, D Capello, G Gaidano, and K Bhatia

Submissions from 1999

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Bax Is frequently compromised in burkitt’s lymphomas with irreversible resistance to fas-induced apoptosis, Marina I. Gutiérrez, Barry Cherney, Azhar Hussain, Howard Mostowski, Giovanna Tosato, Ian Magrath, and Kishor Bhatia

Submissions from 1997

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Sequence variation in EBNA–1 may dictate restriction of tissue distribution of epstein-barr virus in normal and tumor cells, M. I. Gutie!rrez, A. Raj, G. Spangler, A. Sharma, Azhar Hussain, J.-G. Judde, S. W Tsao, P. W .Yuen, I. Joab, I. T. Magrath, and K. Bhatia