Harnessing real-world evidence in paediatric randomised controlled trials
Document Type
Editorial
Department
Centre of Excellence in Women and Child Health; Paediatrics and Child Health (East Africa)
Abstract
Randomised controlled trials (RCTs) provide the highest level of evidence by rigorously evaluating treatments to ensure clinical decisions are grounded in robust data that improve patient outcomes. However, in paediatrics, certain factors can make their conduct more difficult, including recruitment challenges and ethical complexities. There is growing interest in using real-world evidence through routinely collected data (RCD) to improve the design, delivery and applicability of paediatric RCTs across diverse healthcare settings worldwide.
This editorial is part of a series on RCD-enabled studies and their analysis. Other articles will explore the use of real-world evidence in observational research and examine specific analytical methods, including interrupted time series and difference in differences.
AKU Student
no
Publication (Name of Journal)
Archives of Disease in Childhood
DOI
https://doi.org/10.1136/archdischild-2025-329766
Recommended Citation
Tharumakunaraja, R.,
Harman, N. L.,
Dodd, S.,
Sinjanka, Y.,
Nabwera, H.,
Olajide, O.,
Sinha, I. P.
(2026). Harnessing real-world evidence in paediatric randomised controlled trials. Archives of Disease in Childhood.
Available at:
https://ecommons.aku.edu/coe-wch/179