Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group

Authors

Ted K. S. Ng, Arizona State University, USA
Chinedu Momoh, Aga Khan UniversityFollow
Mei-Ann Lim, Universiti Brunei Darussalam, Brunei
Helena Sophia Gleerup, Copenhagen University Hospital Rigshospitalet, Denmark
Wayne Leifert, Commonwealth Scientific and Industrial Research Organisation (CSIRO) Health and Biosecurity, Australia
Catherine Ajalo, Aga Khan University
Nicholas Ashton, Banner Health Foundation and Banner Alzheimer's Foundation, USA
Henrik Zetterberg, University of Gothenburg, Sweden
Robert A. Rissman, University of Southern California, USA
Charisse N. Winston, University of Southern California, USA

Document Type

Article

Department

Brain and Mind Institute

Abstract

There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could complement blood and cerebrospinal fluid and detect various analytes. An interdisciplinary, international group of AD and related dementias (ADRD) researchers convened and performed a narrative review of published studies on salivary AD biomarkers. We critically appraised the current state of the literature, examining both consistencies and discrepancies in existing pre-analytical variables and methodologies. We discussed how various pre-analytical variables could influence the detection and quantification of salivary biomarkers, showed technologies available to standardize collection procedures, and proposed a standardized pre-analytical protocol to guide future studies on salivary AD biomarker examinations. We identified potential contexts of use, gaps, and priorities and proposed future research directions.

Publication (Name of Journal)

Alzheimer's & Dementia

DOI

https://doi.org/10.1002/alz.14420

Recommended Citation

Ng, T. K., Momoh, C., Lim, M., Gleerup, H. S., Leifert, W., Ajalo, C., Ashton, N., Zetterberg, H., Rissman, R. A., Winston, C. N. (2024). Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group. Alzheimer's & Dementia, 1-34.
Available at: https://ecommons.aku.edu/bmi/448

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.