Neurochemical sensitization associated with systemic administration of tumor necrosis factor-alpha: adjuvant action in combination with bovine serum albumin
Document Type
Article
Department
Brain and Mind Institute
Abstract
Tumor necrosis factor-alpha (TNF-alpha) provokes a time-dependent sensitization of brain monoamine activity, plasma corticosterone activity and sickness behavior, the latter being reminiscent of septic or anaphylactic shock. In this investigation, bovine serum albumin (BSA) elicited similar corticosterone and sickness profiles, whereas the monoamine changes were not observed. The sensitization elicited by mTNF-alpha plus BSA was markedly greater than that elicited by BSA alone. Carrier-free TNF-alpha promoted the sensitization of brain monoamine activity, but not sickness or corticosterone. It is suggested that mTNF-alpha acts as an adjuvant to the anaphylactic actions elicited by BSA, but may provoke a sensitization of monoamine activity which is time-dependent and varies across brain regions.
Publication (Name of Journal)
Journal of Neuroimmunology
Recommended Citation
Anisman, H.,
Turrin, N. P.,
Merali, Z.,
Hayley, S.
(2003). Neurochemical sensitization associated with systemic administration of tumor necrosis factor-alpha: adjuvant action in combination with bovine serum albumin. Journal of Neuroimmunology, 145(1-2), 91-102.
Available at:
https://ecommons.aku.edu/bmi/326
Comments
This work was published before the author joined Aga Khan University.