Cardio & reno-protective effect of HDL-C elevation in cholesterol fed rats
Location
Auditorium Pond Side
Start Date
26-2-2014 10:30 AM
Abstract
Introduction: Dyslipidemia plays core role in plaque formation in predisposing the respective organ to impaired blood supply, a common mechanism of ischemic brain, heart & kidney disease. Substantial data suggest that not only hypercholesterolemia but suppressed level of HDL-C is equally important risk factor prompting these perfusion changes. Many pharmacologic & non-pharmacologic interventions are being investigated to increase HDL level.
Objective: The present study was planned to assess the effect of an HDL elevator (Niacin) combined with routine cholesterol lowering (statins) on renal system & atherogenic index. Methodology: Male wistar rats of 200 ± 20g were. After one week of acclimatization, rats were randomly divided into four groups of equal size (n = 6). Group 1 served as control and given normal chow while rest of the groups administered high fat diet (HFD) containing cholesterol, butter fat & oil. Along with this adjusted animal dose of 20mg Atorvastatin to group 3 and 20mg Atorvastatin plus 500mg niacin extended release to group 4 were also given p.o. for eight weeks. All animals were then sacrificed to collect blood & tissue samples. Plasma was separated to measure lipid profile and renal function. Mean values were compared among the groups & p<0.05 chosen as level of statistical significance.
Results: Hypercholesterolemia induced renal function deterioration (r = 0.5, p<0.01). Significant increase (p<0.001) observed in lipid profile in group 2 as compared with control. Statin alone produced significant decrease (p<0.05) in TC, LDL & 30% increase in HDL. While in combination with niacin, there were more pronounced lipid lowering (p<0.01) & significant rise in HDL (p<0.001). The Statin-Statin/Niacin inter group comparison showed significant improvement in renal function; creatinine (p< 0.05), urea (p<0.05) in Niacin treated group.
Conclusion: HDL increasing regime may be useful in prevention from dyslipidemia associated cardio- & renal problems.
Keywords: Dyslipidemia, Niacin, wistar rats, HDL-C
Cardio & reno-protective effect of HDL-C elevation in cholesterol fed rats
Auditorium Pond Side
Introduction: Dyslipidemia plays core role in plaque formation in predisposing the respective organ to impaired blood supply, a common mechanism of ischemic brain, heart & kidney disease. Substantial data suggest that not only hypercholesterolemia but suppressed level of HDL-C is equally important risk factor prompting these perfusion changes. Many pharmacologic & non-pharmacologic interventions are being investigated to increase HDL level.
Objective: The present study was planned to assess the effect of an HDL elevator (Niacin) combined with routine cholesterol lowering (statins) on renal system & atherogenic index. Methodology: Male wistar rats of 200 ± 20g were. After one week of acclimatization, rats were randomly divided into four groups of equal size (n = 6). Group 1 served as control and given normal chow while rest of the groups administered high fat diet (HFD) containing cholesterol, butter fat & oil. Along with this adjusted animal dose of 20mg Atorvastatin to group 3 and 20mg Atorvastatin plus 500mg niacin extended release to group 4 were also given p.o. for eight weeks. All animals were then sacrificed to collect blood & tissue samples. Plasma was separated to measure lipid profile and renal function. Mean values were compared among the groups & p<0.05 chosen as level of statistical significance.
Results: Hypercholesterolemia induced renal function deterioration (r = 0.5, p<0.01). Significant increase (p<0.001) observed in lipid profile in group 2 as compared with control. Statin alone produced significant decrease (p<0.05) in TC, LDL & 30% increase in HDL. While in combination with niacin, there were more pronounced lipid lowering (p<0.01) & significant rise in HDL (p<0.001). The Statin-Statin/Niacin inter group comparison showed significant improvement in renal function; creatinine (p< 0.05), urea (p<0.05) in Niacin treated group.
Conclusion: HDL increasing regime may be useful in prevention from dyslipidemia associated cardio- & renal problems.
Keywords: Dyslipidemia, Niacin, wistar rats, HDL-C