Atherogenic index in different stages of chronic kidney disease
Location
Auditorium Pond Side
Start Date
26-2-2014 10:30 AM
Abstract
Introduction: Cardiovascular problems are the most prevailed complication associated with chronic kidney disease. It is linked with increasing morbidity and mortality in these patients. The underlying pathophysiology includes dyslipidemia not merely hypercholesterolemia. A decrease HDL-C or deranged triglycerides levels are equally important. An early diagnosis and intervention can prevent major health issue by retarding the disease process. That is why we planned this to measure the risk of atherosclerosis in chronic kidney disease patients yet not identified having cardiac problems.
Methodology: The study was executed in collaboration with Nephrology Unit, JPMC, Karachi. Patients coming to OPD with chronic renal disease were requested for consent and respond to questionnaire regarding demographics followed by blood sample collection. Lipid profile for the calculation of atherogenic index and GFR were then measured and categorized on the basis of CKD stage. Patients already on lipid lowering treatments or with cardiovascular disease or clinically manifested atherosclerosis or over age 70 or on dialysis were excluded.
Results: The study was conducted on 500 CKD patients. Most of them were female (65%). The prevailed findings were (hypertension (38%), diabetes mellitus (58%), smoking/oral tobacco (31%) and dyslipidemia (29%). In our studied sample units, high cholesterol was lesser (22%) as compare to low levels of HDL-C (41%) and elevated triglycerides (44%). An increase in atherogenic index was observed with the disease advancement (r = 0.4) that was found significant in stage 3 (p<0.05) and 4 (p<0.01) as compared with that of stage 1. In early stages atherogenic risk is caused by low HDL-C while in later stages its cholesterol that alarms the risk signal. Conclusion: Reduced HDL-C and/or elevated triglycerides are important contributors that add in risk of atherogenesis. Further studies with large sample size are required to make local guideline.
Keywords: Atherogenic Index, CKD, CVD, HDL-C
Atherogenic index in different stages of chronic kidney disease
Auditorium Pond Side
Introduction: Cardiovascular problems are the most prevailed complication associated with chronic kidney disease. It is linked with increasing morbidity and mortality in these patients. The underlying pathophysiology includes dyslipidemia not merely hypercholesterolemia. A decrease HDL-C or deranged triglycerides levels are equally important. An early diagnosis and intervention can prevent major health issue by retarding the disease process. That is why we planned this to measure the risk of atherosclerosis in chronic kidney disease patients yet not identified having cardiac problems.
Methodology: The study was executed in collaboration with Nephrology Unit, JPMC, Karachi. Patients coming to OPD with chronic renal disease were requested for consent and respond to questionnaire regarding demographics followed by blood sample collection. Lipid profile for the calculation of atherogenic index and GFR were then measured and categorized on the basis of CKD stage. Patients already on lipid lowering treatments or with cardiovascular disease or clinically manifested atherosclerosis or over age 70 or on dialysis were excluded.
Results: The study was conducted on 500 CKD patients. Most of them were female (65%). The prevailed findings were (hypertension (38%), diabetes mellitus (58%), smoking/oral tobacco (31%) and dyslipidemia (29%). In our studied sample units, high cholesterol was lesser (22%) as compare to low levels of HDL-C (41%) and elevated triglycerides (44%). An increase in atherogenic index was observed with the disease advancement (r = 0.4) that was found significant in stage 3 (p<0.05) and 4 (p<0.01) as compared with that of stage 1. In early stages atherogenic risk is caused by low HDL-C while in later stages its cholesterol that alarms the risk signal. Conclusion: Reduced HDL-C and/or elevated triglycerides are important contributors that add in risk of atherogenesis. Further studies with large sample size are required to make local guideline.
Keywords: Atherogenic Index, CKD, CVD, HDL-C