12 hours post admission troponin T levels are consistent with the infarct size in patients with ST segment elevation myocardial infarction.
Location
Auditorium Pond Side
Start Date
26-2-2014 10:30 AM
Abstract
Background: Current guidelines recommend the use of Troponin T as biomarker of choice for the diagnosis of AMI. Data revealing relationship between TNT and infarct size in patients with STEMI are limited.
Objective: To evaluate the relationship between cardiac TnT levels with infarct size measured by ECG and Echo in patients with STEMI. Methods: It is a prospective analysis of 116 consecutive patients with STEMI who were brought to the CCU. Their ECGs were recorded at the time of admission and Troponin T levels were measured at 12 hours of their presentation to the hospital. Their Echo was done 48 hours post admission. The relationship between infarct size and TnT levels was studied.
Results: A total of 116 consecutive patients (age, 58 ± 17 years; 18% women) with STEMI were studied. The areas of infarction determined by ECG Vs Echo were IWMI in 37% Vs 36%, ASMI in 19% Vs 20%, ALMI in 18% & Extensive anterior in 13% Vs ALMI 36%, PWMI in 4% Vs IPMI in 5% respectively and 2% were global in location on ECG. Regarding levels of TnT, 48% had high positive i,e >2.0ng/ml, 52% had quantitative readings (20% had 1.51-2.0ng/ml, 18% had 1.0-1.50ng/ml and 14% had 0.51-1.0ng/ml). None of them had low positive value i,e <0.1ng/ml. The mean value of Troponin T in PWMI is 1.11ng/ml, IWMI is 1.23ng/ml, LWMI is 1.33ng/ml, ASMI is 1.62ng/ml and for ALMI, Extensive MI and global MI is >2.0ng/ml
Conclusion: TnT is a reliable and cost effective tool at 12 hours post STEMI to aid in quantification of infarct size measured by ECG and Echo. It can also gives us a clue of bedside evaluation of post MI LV function which can later be revealed by much expensive cardiac MRI and SPECT Myocardial perfusion imaging scans.
Keywords: ASMI- Anteroseptal Myocardial Infarction, ALMI- Anterolateral Myocardial Infarction, IWMI-Inferior Myocardial Infarction, IPMI- Infero-posterior MI
12 hours post admission troponin T levels are consistent with the infarct size in patients with ST segment elevation myocardial infarction.
Auditorium Pond Side
Background: Current guidelines recommend the use of Troponin T as biomarker of choice for the diagnosis of AMI. Data revealing relationship between TNT and infarct size in patients with STEMI are limited.
Objective: To evaluate the relationship between cardiac TnT levels with infarct size measured by ECG and Echo in patients with STEMI. Methods: It is a prospective analysis of 116 consecutive patients with STEMI who were brought to the CCU. Their ECGs were recorded at the time of admission and Troponin T levels were measured at 12 hours of their presentation to the hospital. Their Echo was done 48 hours post admission. The relationship between infarct size and TnT levels was studied.
Results: A total of 116 consecutive patients (age, 58 ± 17 years; 18% women) with STEMI were studied. The areas of infarction determined by ECG Vs Echo were IWMI in 37% Vs 36%, ASMI in 19% Vs 20%, ALMI in 18% & Extensive anterior in 13% Vs ALMI 36%, PWMI in 4% Vs IPMI in 5% respectively and 2% were global in location on ECG. Regarding levels of TnT, 48% had high positive i,e >2.0ng/ml, 52% had quantitative readings (20% had 1.51-2.0ng/ml, 18% had 1.0-1.50ng/ml and 14% had 0.51-1.0ng/ml). None of them had low positive value i,e <0.1ng/ml. The mean value of Troponin T in PWMI is 1.11ng/ml, IWMI is 1.23ng/ml, LWMI is 1.33ng/ml, ASMI is 1.62ng/ml and for ALMI, Extensive MI and global MI is >2.0ng/ml
Conclusion: TnT is a reliable and cost effective tool at 12 hours post STEMI to aid in quantification of infarct size measured by ECG and Echo. It can also gives us a clue of bedside evaluation of post MI LV function which can later be revealed by much expensive cardiac MRI and SPECT Myocardial perfusion imaging scans.
Keywords: ASMI- Anteroseptal Myocardial Infarction, ALMI- Anterolateral Myocardial Infarction, IWMI-Inferior Myocardial Infarction, IPMI- Infero-posterior MI