Incidence of Typhoid Bacteremia in Infants and Young Children in Southern Coastal Pakistan
Paediatrics and Child Health
Introduction: The burden of typhoid fever in preschool children is not well recognized. The Purpose of this study was to estimate the incidence of typhoid bacteremia in Pakistani children age, with a focus on children younger than 2 years of age. This will help to inform prevention policies in highly endemic countries. Methods: Household surveillance from February 1, 2007 to May 12, 2008, was carried out by community health workers in 2 low-income, coastal communities of Karachi. Workers referred each sick child consent, and inoculated in BACTEC Peds Plus bottles (Becton Dickinson, Sparks, MD) and processed per manufacturer's guidelines. Results: Overall, 5570 children contributed 3949 observation years. Blood culture was obtained from 1165 cases, yielding 36 pathogens. Salmonella Typhi was isolated in 16 cases, Salmonella Paratyphi A in 2 cases, and Salmonella Paratyphi B in 1 case. The incidence of typhoid bacteremia in children (95% confidence interval, 193.8-876.5) per 100,000 child years. The overall incidence rate of typhoid for children (95% confidence interval, 239.8-643.9) per 100,000 child years. Conclusion: Typhoid is a common and significant cause of morbidity among young children in Pakistan, including children less than 2 years of age. Vaccines that provide protection to preschool children should be included in typhoid control efforts.
Pediatric Infectious Disease Journal
(2010). Incidence of Typhoid Bacteremia in Infants and Young Children in Southern Coastal Pakistan. Pediatric Infectious Disease Journal, 29(11), 1035-1039.
Available at: http://ecommons.aku.edu/pakistan_fhs_mc_women_childhealth_paediatr/96