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OBJECTIVE: To compare the analgesic efficacy of Bupivacaine 0.25% wound infiltration with Ketorolac incisional infiltration in relieving postoperative pain for first twenty-four hours.

METHODOLOGY: Analytical, interventional and comparative study was performed on seventy patients, of both sexes, with varied age groups. Patients underwent minor and moderate surgeries, confined to American Society of Anaesthesiologist ASA category 1-II. Patients were selected by convenience sampling and were divided into two groups i.e. Group I and Group II. Group-I comprised of thirty five patients and were infiltrated with Bupivacaine 0.25% at wound margins postoperatively. Group-II also comprised of thirty-five patients and were infiltrated with Ketorolac at wound margins 60 mg postoperatively.

RESULTS: Bupivacaine 0.25% wound infiltration had onset of action within 4 +/- 2 minutes. Percentage pain relief was 80% in minor surgeries and 60% in moderate surgeries. Duration of action lasted for 8 +/- 2 hours regarding minor surgeries while it was 6 +/- 1 hours for moderate surgeries. Ketorolac incisional infiltration had onset of analgesic action within 10 +/- 5 minutes. Duration of action lasted for 6 +/- 1 hours regarding minor surgeries while it was 4 +/- 2 hours regarding moderate surgeries. Percentage pain relief was 60% in minor surgeries and 50% in moderate surgeries.

CONCLUSION: Wound infiltration with Bupivacaine 0.25% was better for postoperative pain relief in comparison with Ketorolac regarding percentage pain relief, onset and duration of action.


Journal of the Pakistan Medical Association