Anti-hypertensive medication use, soluble receptor for glycation end products and risk of pancreatic cancer in the women's health initiative study

Authors

Zhensheng Wang, Baylor College of Medicine, Houston, TX
Donna L. White, Baylor College of Medicine, Houston, TX
Ron Hoogeveen, Baylor College of Medicine, Houston, TX
Liang Chen, Baylor College of Medicine, Houston, TX
Eric A. Whitsel, University of North Carolina at Chapel Hill, Chapel Hill, USA
Peter A. Richardson, Baylor College of Medicine, Houston, TX
Salim S. Virani, Baylor College of Medicine, Houston, TXFollow
Jose M. Garcia, University of Washington, Seattle, WA
Hashem B. El-Serag, Baylor College of Medicine, Houston, TX
Li Jiao, Baylor College of Medicine, Houston, TX

Document Type

Article

Department

Cardiology

Abstract

Pancreatic cancer is the fourth leading cause of cancer death. Soluble receptor for glycation end products (sRAGE), which is modulated by anti-hypertensive (HT) medications, has been inversely associated with pancreatic cancer. However, the association between commonly used anti-HT medications and risk of pancreatic cancer is unknown. A total of 145,551 postmenopausal women from the Women Health Initiative (WHI) Study were included in analysis. Use of angiotensin converting enzyme inhibitors (ACEi), β-blockers, calcium channel blockers (CCBs) and diuretics was ascertained at baseline (1993⁻1998). Baseline sRAGE levels were measured among a subset of 2104 participants using an immunoassay. Multivariable Cox proportional hazard regression model was performed to estimate hazard ratios (HRs) and its 95% confidence intervals (CIs) for pancreatic cancer in association with anti-HT medications. Increased risk of pancreatic cancer was found among users of short-acting CCB (HR = 1.66, 95% CI: 1.20⁻2.28) and long-term (≥3 years) users of short-acting CCB (HR = 2.07, 95% CI: 1.42⁻3.02) compared to users of other anti-HT medications. Average sRAGE levels were lower in short-acting CCB users than users of other anti-HT medications (1173 versus 1454 pg/mL, p = 0.038). Non-statistically significant reduced risk of pancreatic cancer was found among users of β-blockers (HR = 0.80, 95% CI: 0.60⁻1.07). Average sRAGE levels were higher in β-blockers users than users of other anti-HT medications (1692 versus 1454 pg/mL, p > 0.05). Future studies are warranted to confirm these findings and elucidate potential mechanisms by which anti-HT medications influence development of pancreatic cancer

Comments

Pagination are not provided by the author/publisher. This work was published before the author joined Aga Khan University

Publication ( Name of Journal)

Journal of Clinical Medicine

Recommended Citation

Wang, Z., White, D. L., Hoogeveen, R., Chen, L., Whitsel, E. A., Richardson, P. A., Virani, S. S., Garcia, J. M., El-Serag, H. B., Jiao, L. (2018). Anti-hypertensive medication use, soluble receptor for glycation end products and risk of pancreatic cancer in the women's health initiative study. Journal of Clinical Medicine, 7(8).
Available at: https://ecommons.aku.edu/provost_office/454