Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles
Background: This study evaluated a possible relationship between levels of endothelial microparticles (EMPs), known to be a sensitive indicator of endothelial disturbance, and changes in postprandial lipid levels in healthy volunteers after a low- or high-fat meal.
Methods and results: Eighteen healthy subjects without known cardiovascular risk factors were evaluated. Lipid and EMP levels were measured before and 1 and 3 hours after a single low- or high-fat isocaloric meal. The low-fat meal had no significant postprandial effect on EMPs or lipids compared with fasting levels. In contrast, a single high-fat meal significantly increased EMP levels after 1 and 3 hours, from 389+/-54 (thousands per milliliter) when fasting to 541+/-139 (P=0.0002) and 677+/-159 (P<0.0001), respectively, and correlated with a postprandial elevation in serum triglycerides.
Conclusions: A single high-fat meal led to a significant elevation of plasma EMP levels in healthy, normolipidemic subjects and correlated with a postprandial elevation of serum triglycerides. EMPs may be an indirect marker of endothelial dysfunction or injury induced by postprandial triglyceride-rich lipoproteins.
Ferreira, A. C.,
Peter, A. A.,
Mendez, A. J.,
Jimenez, J. J.,
Mauro, L. M.,
Chirinos, J. A.,
Virani, S. S.,
Horstman, L. L.
(2004). Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles. Circulation, 110(23), 3599-3603.
Available at: https://ecommons.aku.edu/provost_office/313
This work was published before the author joined Aga Khan University.