Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men
Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.
The American Journal of Cardiology
Chirinos, J. A.,
Zambrano, J. P.,
Virani, S. S.,
Jimenez, J. J.,
Horstman, L. L.,
Myerburg, R. J.,
Ahn, Y. S.
(2005). Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men. The American Journal of Cardiology, 95(10), 1258-1260.
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This work was published before the author joined Aga Khan University.