Hope in The Face Of Subacute Sclerosing Panencephalitis: A Case Report Of Complete Remission With Isoprinosine

AKU Student

no

Authors

Nimra Shafique, Bolan University of Medical & Health Sciences, Quetta
Syed Muhammad Essa, Bolan University of Medical & Health Sciences, Quetta
Amanullah Kakar, Bolan University of Medical & Health Sciences, Quetta

Document Type

Case Report

Abstract

Subacute Sclerosing Panencephalitis (SSPE) is a rare and relentless neurodegenerative disorder linked to persistent measles virus infection. We present a case of a 16-year-old female with gradually worsening rigidity, cognitive decline, and myoclonic seizures, minimally responsive to valproic acid. A history of measles infection at the age of two years emerged. Positive cerebrospinal fluid (CSF) IgG and IgM anti-measles antibodies, along with an elevated CSF/serum antibody index, confirmed SSPE. Treatment with Inosine pranobex and clonazepam yielded significant motor and seizure control improvements. This case highlights the importance of early SSPE diagnosis and tailored interventions, shedding light on clinical progression and therapeutic responses.

Recommended Citation

Shafique, Nimra; Essa, Syed Muhammad; and Kakar, Amanullah (2025) "Hope in The Face Of Subacute Sclerosing Panencephalitis: A Case Report Of Complete Remission With Isoprinosine," Pakistan Journal of Neurological Sciences (PJNS): Vol. 20: Iss. 1, Article 4.
Available at: https://ecommons.aku.edu/pjns/vol20/iss1/4