Valproate is one of the oldest known anti-epileptic drugs (AED) in practice which was discovered in 1881 and later in 1962 was approved for treating epilepsy. It is indicated in most of the seizure types including generalized onset (motor, non-motor and myoclonic), focal onset, unknown onset and unclassified. Valproate has other indications in migraine prophylaxis, and bipolar disorder.
Mansoor, Salman; Murphy, Kevin; Kelly, Siobhan; and Saadat, Shoab
"Valproate Used in Women of Childbearing Age with Epilepsy,"
Pakistan Journal of Neurological Sciences (PJNS): Vol. 16:
2, Article 7.
Available at: https://ecommons.aku.edu/pjns/vol16/iss2/7