Determine if hypomagnesemia & hypocalcemia on admission was associated with ICH and outcome.
Magnesium is a vascular smooth muscle relaxant and appears to provide protection against cellular injury in experimental stroke models. The implication of low serum magnesium in primary ICH is not well defined.
All patients with a primary ICH presented to PIMS, Islamabad prospectively analyzed in a pilot study. Demographics, initial lab values, ICH location, Mg+2 level, NIHSS & MRS at presentation were recorded. All patients with INR <= 1.5 were included in this study. We took normal serum magnesium in our study was 1.8 - 2.5 mEq/dL. Statistical significance was determined using linear regression adjusting for admission systolic blood pressure (SBP).
We identified 66 patients who met the inclusion criteria. The mean age was 52.76 years with minimum and maximum age was 25 and 80 years respectively. Total male and female patients were 40 (61%) and 26 (39.4%). The total number of patients with hypomagnesemia was 23 (30%) and with hypocalcemia was 54 (65%). All patients having hypomagnesemia (30%) also had subsequent hypocalcemia. Mean systolic Blood pressure (SBP) was 156.65 mmHg and 55patients (84.62%) presented with high SBP. All patients with hypomagnesemia presented with high SBP (p=0.001). Hypomagnesemia and hypocalcemia both were showed statically significant association with poor MRS & NIHSS score (p=0.013 and p=0.001). Hypomagnesemia was not showed statistically significant relation with the outcome (p=0.11) while hypocalcemia showed a remarkable association with outcome (p=0.001).
Hassan, Muhammad; Khan, Naveed Ullah; Iqbal, Mansoor; Rajput, Haris Majid; Rehman, Ehsan-Ur-; Shahzad, Waleed; and Badshah, Mazhar
"Association of Hypomagnesaemia & Hypocalcemia with Intracerebral Hemorrhage and Outcome,"
Pakistan Journal of Neurological Sciences (PJNS): Vol. 16:
2, Article 5.
Available at: https://ecommons.aku.edu/pjns/vol16/iss2/5