Extended window intravenous thrombolysis: Is conventional window of 4.5 hours coming To an end?

Authors

Malik Muhammad Adil, Johns Hopkins University School of Medicine. Medical Director Stroke Program, Suburban Hospital, Johns Hopkins, BethesdaFollow
Narmeen Masood, Aga Khan University, Karachi

Document Type

Editorial

Abstract

The current standard of care to treat acute stroke patients presenting within 4.5 hours of stroke symptom onset is intravenous (IV) Alteplase.1 Over the past decade, tremendous efforts have been made to challenge the conventional window of 4.5 hours for the administration of Alteplase to expand the patient population which can benefit from thrombolysis. Based on the recent meta-analysis, 2 we have strong evidence supporting the use of IV thrombolysis in patients presenting between 4.5 to 9 hours of symptom onset with favorable perfusion imaging and it appears that the era of the conventional 4.5 hours window may be coming to an end"

Recommended Citation

Muhammad Adil, Malik and Masood, Narmeen (2019) "Extended window intravenous thrombolysis: Is conventional window of 4.5 hours coming To an end?," Pakistan Journal of Neurological Sciences (PJNS): Vol. 14: Iss. 3, Article 12.
Available at: https://ecommons.aku.edu/pjns/vol14/iss3/12