Polyneuropathy associated with iga Paraproteinemia: a case report and literature Review.

Authors

Waleed Shahzad, Pakistan Institute of Medical Sciences Islamabad
Sumaira Nabi, Pakistan Institute of Medical Sciences Islamabad
Hafiza Faiza Mushtaq, Pakistan Institute of Medical Sciences Islamabad
Tehmina Inayat, Pakistan Institute of Medical Sciences Islamabad
Muhammad Hassan, Pakistan Institute of Medical Sciences Islamabad
Haris Majid Rajput, Pakistan Institute of Medical Sciences Islamabad
Zakir Jan, Pakistan Institute of Medical Sciences Islamabad
Mazhar Badshah, Pakistan Institute of Medical Sciences Islamabad

Document Type

Case Report

Abstract

Paraproteinemia is precipitated by an accumulation of monoclonal plasma cells or B lymphocytes. Idiopathic neuropathies that are associated with paraproteinemia account for only 10% of the neuropathies. Paraprotein acts like an antibody and is targeted against myelin and axons present in the peripheral nerves. Despite being of interest for quite a long time, the caudal relationship between paraproteinemias and peripheral neuropathies still remains a sorcery. We report a case of a middle aged male who presented with pain and parasthesias in both arms and legs. His workup revealed him to be having a paraproteinemic neuropathy consistent with IgA Lambda chains that account for being the most rare type of monoclonal gammopathy than IgM or IgG having the potential to progress to smouldering multiple myeloma.

Recommended Citation

Shahzad, Waleed; Nabi, Sumaira; Mushtaq, Hafiza Faiza; Inayat, Tehmina; Hassan, Muhammad; Rajput, Haris Majid; Jan, Zakir; and Badshah, Mazhar (2019) "Polyneuropathy associated with iga Paraproteinemia: a case report and literature Review.," Pakistan Journal of Neurological Sciences (PJNS): Vol. 14: Iss. 2, Article 2.
Available at: https://ecommons.aku.edu/pjns/vol14/iss2/2