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Original Article


Brain Derived Neurotrophic Factor (BDNF) is a brain protein implicated in learning, memory and other cognitive functions. Changes in cellular brain functions as well as cognitive defects have been observed the days following anaesthesia, even for short-duration anaesthesia with/without surgery. Despites the role of neurotrophic factors in cognition, no data are still available on brain effects after anaesthesia. Purpose: To study the effect of minor surgery under short duration anaesthesia on cognition by investigating BDNF levels in plasma, hippocampus and cortex. METHODS: Male rats received an intra-peritoneal injection of either 120 mg/kg of propofol or intralipids solution or minor surgery was performed under propofol anaesthesia. The animals were euthanized at ZT5 (peak of the circadian profile of brain BDNF in rat) after 3 days and brain homogenates of prefrontal Cortex and Hippocampus were prepared and blood was also collected for plasma. The amount of BDNF was assessed using ELISA (Millipore) on supernatant.

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