Document Type

Original Article


Guillain-Barré syndrome (GBS) is one of the most frequent disorder of peripheral nervous system associated with respiratory distress. One clinical parameter that was found significant in heralding the onset of respiratory failure in GBS weresensory manifestations. The aim of the study was to determine the frequency of respiratory distress in patients of GuillainBarresyndrome with or without sensory manifestations in the disease. MATERIALS AND METHODS: This was a descriptive case seriesthat was conducted from January 19, 2013 to July 18, 2013 in Department of Neurology, Pakistan Institute of Medical Sciences, Islamabad. All patients who met the inclusion criteria were selected for the study. Sensory manifestations of GBS were determined clinically, and patients were divided into two groupsi.e patients with sensory manifestations and without sensory manifestations. These two groups were followed for a period of 10 days and monitored for the presence of respiratory distress. RESULTS: A total of 110 patients were included. The mean age of patients was 34.41 years with standard deviation of 17.12 years. 76 (69.09%) patients were male and 34 (30.91%) patients were female. 85 patients had sensory manifestations while 25 patients had no sensory manifestations. 33 patients of GBS with sensory manifestation had respiratory distress while 52 patients had no respiratory distress.CONCLUSION: In our study moderate to severe pain is a common and early symptom of Guillain-Barre Syndrome. Respiratory involvement is more common in patients with sensory manifestation. Early detection and aggressive treatment of sensory manifestations of GuillainBarresyndrome should be a part of initial management so as to minimize the risk of respiratory failure.

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