Document Type

Original Article


Miller fisher syndrome is generally considered a rare but important variant of Guillain Barré Syndrome (GBS) having geographically variable incidence. Patients with this clinical syndrome are often misdiagnosed and mismanaged due to lack of awareness on the part of physician. Objective: To determine frequency of Miller fisher syndrome (MFS), variant of GBS in patients presenting to a tertiary care hospital in Karachi. Methods: This descriptive cross sectional study was conducted in the Department of Neurology, Jinnah Postgraduate Medical Centre (JPMC), Karachi. The duration was from April, 2014 to April, 2016 (two years). A total of 100 patients were included in this study. Patients were classified into GBS, MFS and GBS/MFS overlap according to their clinical presentation, CSF analysis and electrophysiological findings. Data was collected on a predesigned proforma. Results: Out of 100 cases, 62 (62%) were males and 38 (38%) were females. Frequency of Miller fisher syndrome (MFS) in patients of GBS was 14% predominantly involving male, with male to female ratio is 6:1.Majority of patients had duration of symptoms for 11 ± 6 days before presentation. The mean age of patients with MFS was 46.03years (SD±12.6). Conclusion: We report a high frequency of MFS in our population with predominant involvement of male gender.

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