Granulocytic sarcoma (chloroma) is an extramedullary solid tumor composed of immature white blood cells. Most common involvement sites are bone, periostium, soft tissue, lymph nodes and skin. Intracranial granulocytic sarcoma rarely occurs in meningeal or parenchymal form1. We report the of concurrent occurrence of intracranial chloromas and leukemia cutis in 26 years old male patient, known case of Chronic Myeloid Leukemia for 3 years [+ve Philadelphia (Ph) chromosome in bone marrow cells] who now presented to the Civil Hospital Karachi with continuous headache and multiple cutaneous nodules all over the body for last 2 months. The CT exam of the Head revealed multiple hyper dense extra-axial nodular masses (with mean value of 48 HU) which showed vivid enhancement on post contrast images, along with multiple subcutaneous enhancing nodules seen in the scalp and maxillofacial region. The CSF cytological examination confirmed presence of immature leukemic cells in the subarachnoid space. The subcutaneous chest nodule histopathology showed granulocytic sarcoma. To the best of authors’ knowledge, the concurrent occurrence of granulocytic sarcomas at different locations in a single patient with Chronic Myeloid Leukemia has not been reported earlier in the literature.
Ahmed Khan, Ateeque and Hafeez, Mahnoor
"Concurrent intracranial chloromas and leukemia cutis in chronic myeloid leukemia,"
Pakistan Journal of Neurological Sciences (PJNS): Vol. 11:
4, Article 8.
Available at: https://ecommons.aku.edu/pjns/vol11/iss4/8