Correlation between laparoscopic and histopathologic diagnosis of endometriosis

Sikolia Z. Wanyonyi
Evan Sequeira
Samuel G. Mukono


Objective: To review the histopathologic diagnosis of biopsies taken following visualization of endometriosis at laparoscopy and to correlate visual with microscopic diagnoses.

Methods: A retrospective review was undertaken of medical charts with a diagnosis of endometriosis at Aga Khan University Hospital, Nairobi, Kenya, between January 2001 and October 2010. Eligibility included visual diagnosis of endometriosis at laparoscopy, with a clear record of site, size, morphology, and number of lesions. The histopathologic diagnosis of the biopsies sampled was sought. Correlation was undertaken using K statistics for diagnostic variability.

Results: Of the 204 relevant records, 152 (74.5%) met the eligibility criteria, from these cases, 239 specimens were submitted for histology. The most common symptom was chronic pelvic pain (108[71.1%]). Most biopsies were obtained from the ovary and posterior cul-de-sac. Histopathologic diagnosis was confirmed in (152 [63.8%]) specimens and correlated with Asian race, multiparity, and chronic pelvic pain. Neither the site of the lesion nor the stage of disease influenced the histopathologic diagnosis.

Conclusion: Laparoscopic visualization of endometriosis does not always correlate with histopathologic diagnosis, several other lesions may mimic endometriosis on histopathologic examination.