Title

Anti-estrogen induced synthesis of transforming growth factor-beta in breast cancer patients

Document Type

Article

Department

Radiation Oncology

Abstract

Estrogen receptor-negative human breast cancer is usually an aggressive, hormone independent tumour. Recent studies show that growth of these tumours could be influenced by anti-estrogens. Anti-estrogens appear to stimulate the production of Transforming Growth Factor-beta (TGF-beta) in hormone dependent as well as independent cell lines suggesting as a result inhibition of cellular proliferation of these cell lines by TGF-beta through an autocrine/paracrine mechanism.

Publication

Cancer Treatment Reviews

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