Anti-estrogen induced synthesis of transforming growth factor-beta in breast cancer patients
Estrogen receptor-negative human breast cancer is usually an aggressive, hormone independent tumour. Recent studies show that growth of these tumours could be influenced by anti-estrogens. Anti-estrogens appear to stimulate the production of Transforming Growth Factor-beta (TGF-beta) in hormone dependent as well as independent cell lines suggesting as a result inhibition of cellular proliferation of these cell lines by TGF-beta through an autocrine/paracrine mechanism.
Cancer Treatment Reviews
Mirza, M. R.
(1991). Anti-estrogen induced synthesis of transforming growth factor-beta in breast cancer patients. Cancer Treatment Reviews, 18(2), 145-148.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_radiat_oncol/52