Bone marrow necrosis - initial presentation in sickle cell anemia
Pathology and Laboratory Medicine
Patient: Male, 20 FINAL DIAGNOSIS: Sickle cell anemia Symptoms: Bone marrow necrosis bone pain fever hepatomegaly icterus splenomegaly weaknessMEDICATION: - Clinical Procedure: - Specialty: Hematology.
Unusual clinical course.
In sickle cell disease, bone involvement is the commonest clinical presentation in the acute as well as chronic setting presenting as painful vaso-occlusive crisis and avascular necrosis, respectively. Other complications include bone marrow necrosis and infarction.
We report a case of a 20-year-old male who was referred for bone marrow evaluation due to symptoms of fever, weakness, and repeated episodes of bone pains. Bone trephine biopsy revealed multiple areas of central necrosis surrounded by fibroblasts.
Recognition of necrosis through bone trephine biopsy is important for early initiation of therapy.
The American Journal of Case Reports
(2013). Bone marrow necrosis - initial presentation in sickle cell anemia. The American Journal of Case Reports, 14, 416-418.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/774