Extra pulmonary accumulation of Tc-99m-macroaggregate of albumin (MAA) is rarely seen on perfusion lung scan, and has been reported in less than 4% of a study population of nearly 380 patients1. It occurs when the agent bypasses the lungs due to a right to left (R-L) cardiac or pulmonary shunt, when it is shunted to the portal vein before reaching the right atrium and ventricle of the heart, and when the agent is degraded to a submicron particle size.2 When a pharmaceutical problem is excluded, extra-pulmonary uptake implies unusual hemodynamics with a shunt.
Journal of the Pakistan Medical Association
Khan, S. A.,
Ahmad, M. N.
(2006). Extra pulmonary uptake of Tc-99m-MAA perfusion lung scan as a result of right to left intra cardiac shunt. Journal of the Pakistan Medical Association, 56(5), 241-242.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/694