Title
Stimulation of defective Gunn-rat Liver Uridine diphosphate Glucuronyltransferase activity in vitro by Alkyl ketones
Document Type
Article
Department
Pathology and Microbiology
Abstract
Addition of alkyl ketone (10mM) to Gunn-rat liver homogenates increased UDP-glucuronyltransferase activity towards 2-aminophenol by 10--20 fold, up to enhanced values of enzyme activity observed with similarly treated Wistar-rat liver homogenates. Alkyl ketones also activate the defective enzyme purified from Gunn-rat liver. This genetic deficiency of UDP-glucuronyltransferase activity is no longer apparent when assayed in the presence of alkyl ketones.
Publication
Biochemical Journal
Recommended Citation
Lalani, E.,
B, B.
(1979). Stimulation of defective Gunn-rat Liver Uridine diphosphate Glucuronyltransferase activity in vitro by Alkyl ketones. Biochemical Journal, 177(3), 993-995.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/430