Stimulation of defective Gunn-rat Liver Uridine diphosphate Glucuronyltransferase activity in vitro by Alkyl ketones
Document Type
Article
Department
Pathology and Microbiology
Abstract
Addition of alkyl ketone (10mM) to Gunn-rat liver homogenates increased UDP-glucuronyltransferase activity towards 2-aminophenol by 10--20 fold, up to enhanced values of enzyme activity observed with similarly treated Wistar-rat liver homogenates. Alkyl ketones also activate the defective enzyme purified from Gunn-rat liver. This genetic deficiency of UDP-glucuronyltransferase activity is no longer apparent when assayed in the presence of alkyl ketones.
Publication (Name of Journal)
Biochemical Journal
Recommended Citation
Lalani, E.,
B, B.
(1979). Stimulation of defective Gunn-rat Liver Uridine diphosphate Glucuronyltransferase activity in vitro by Alkyl ketones. Biochemical Journal, 177(3), 993-995.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/430