The inherited deficiency of Hepatic UDP-Glucuronyltransferase: Structure-activity relationships of in Vitro Stimulators
Pathology and Microbiology
More than 18 compounds have been tested for their ability to stimulate defective UDP-glucuronyltransferase activity of Gunn rat liver homogenates towards 2-aminophenol, up to levels of transferase activity in similarly treated Wistar rat liver homogenates. The minimum structural requirements of an effective compound are a combination of the presence of an electron-attracting atom or group and a sparing solubility in water. The activation of defective UDP-glucuronyltransferase towards 2-aminophenol by pentan-3-one is reversible. The possible mechanism of action of alkyl ketone activators is discussed.
Publication (Name of Journal)
J, W. P.,
M, K. S.
(1980). The inherited deficiency of Hepatic UDP-Glucuronyltransferase: Structure-activity relationships of in Vitro Stimulators. Biochemical Pharmacology, 29(17), 2367-2371.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/429