The inherited deficiency of Hepatic UDP-Glucuronyltransferase: Structure-activity relationships of in Vitro Stimulators
Pathology and Microbiology
More than 18 compounds have been tested for their ability to stimulate defective UDP-glucuronyltransferase activity of Gunn rat liver homogenates towards 2-aminophenol, up to levels of transferase activity in similarly treated Wistar rat liver homogenates. The minimum structural requirements of an effective compound are a combination of the presence of an electron-attracting atom or group and a sparing solubility in water. The activation of defective UDP-glucuronyltransferase towards 2-aminophenol by pentan-3-one is reversible. The possible mechanism of action of alkyl ketone activators is discussed.
J, W. P.,
M, K. S.
(1980). The inherited deficiency of Hepatic UDP-Glucuronyltransferase: Structure-activity relationships of in Vitro Stimulators. Biochemical Pharmacology, 29(17), 2367-2371.
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