Rhabdomyosarcoma--an Epidemiological and Histopathologic study of 277 cases from a major tertiary care center in Karachi, Pakistan
Pathology and Microbiology
Aim: To present the epidemiologic data (age, gender, size etc) and histopathologic and immunohistochemical features of cases of rhabdomyosarcoma (RMS) reported in our department.
Settings: Section of Histopathology,Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, Pakistan.
Duration: All cases of RMS diagnosed between January 1, 2003 and December 31, 2012 were included in the study.
Results: A total of 277 cases were included. Embryonal rhabdomyosarcoma (ERMS) was by far the dominant histologic type (87.4%) followed by alveolar type (ARMS)(9.4%). ERMS was much more common in males (64.0%)and over 65% of cases occurred in the first decade of life (over 90% in the first two decades). Head and neck region was commonest site for ERMS (46.7%), followed by the genitourinary system (16.1%). Over 65% cases of ARMS occurred in the extremities. Over 80% cases of ARMS occurred in the first 3 decades of life. Immunohistochemical staining for Desmin and MyoD1 was positive in 96.7% and 85.4% respectively.
Conclusions: The epidemiologic data and microscopic findings in our patients are similar to international published data on rhabdomyosarcoma.
Publication ( Name of Journal)
Asian Pacific Journal of Cancer Prevention
U, D. N.,
(2015). Rhabdomyosarcoma--an Epidemiological and Histopathologic study of 277 cases from a major tertiary care center in Karachi, Pakistan. Asian Pacific Journal of Cancer Prevention, 16(2), 757-760.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/412