Title
Suppressor of Cytokine signaling-1 and Chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous Necrosis in Granulomas from patients with Tuberculous Lymphadenitis
Document Type
Article
Department
Pathology and Microbiology
Abstract
We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.
Publication ( Name of Journal)
Journal of Microbiology, Immunology, and Infection
Recommended Citation
I, M. K.,
Pervez, S.,
E, R. M.,
B, U.,
Z, H.
(2015). Suppressor of Cytokine signaling-1 and Chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous Necrosis in Granulomas from patients with Tuberculous Lymphadenitis. Journal of Microbiology, Immunology, and Infection.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/407