eCommons@AKU

Title

Suppressor of Cytokine signaling-1 and Chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous Necrosis in Granulomas from patients with Tuberculous Lymphadenitis

Authors

Masood K. I, Aga Khan University
Shahid Pervez, Section of Histopathology, Dept of Pathology & Laboratory Medicine, Aga Khan University Hospital, KarachiFollow
Rottenberg M. E, Karolinska Institutet
Umar B, Aga Khan University
Hasan Z, Aga Khan UniversityFollow

Document Type

Article

Department

Pathology and Microbiology

Abstract

We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.

Publication ( Name of Journal)

Journal of Microbiology, Immunology, and Infection

Recommended Citation

I, M. K., Pervez, S., E, R. M., B, U., Z, H. (2015). Suppressor of Cytokine signaling-1 and Chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous Necrosis in Granulomas from patients with Tuberculous Lymphadenitis. Journal of Microbiology, Immunology, and Infection.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/407