TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines.
Pathology and Microbiology
We have recently demonstrated that human TFF2 inhibits apoptosis in the non-TFF2 expressing breast adenocarcinoma cell line MCF-7. In this study we examined the impact of TFF2 and an anti-TFF2 antibody (hSP3) on the survival of other human adenocarcinoma cell lines; TFF2-positive (LS174T and SW480) and TFF2-negative (MCF-7 and T47D). Addition of TFF2 protected the (TFF2–) lines but had no effect on those constitutively expressing TFF2. Blocking with hSP3 significantly increased apoptosis in the (TFF2+) cell lines with minimal effect on the (TFF2–) cells. Our results show that the cytoprotective effect of TFF2 seen in MCF-7 cells is not cell line-specific and can be abrogated by inhibition of its expression.
Sui, L., Romanska, H., Abel, P. D., Kayademir, M., Bous-Loncar, N., Stamp, G. W., & Lalani, E. (2004). TFF2 (trefoil family factor 2) inhibits apoptosis in breast and colorectal cancer cell lines. Peptides, 25(5), 855-863.