Document Type
Article
Department
Pathology and Microbiology
Abstract
OBJECTIVE: To determine whether receptor status and HER-2/neu status remains same in primary and metastatic breast carcinoma to corresponding lymph nodes of individual patients.
METHODS: Estrogen receptors, progesterone receptors and HER-2/neu immunohistochemical stains were performed on primary and metastatic breast carcinoma to axillary lymph nodes in 100 patients. Data was collected on a Performa and age, tumour size, type, grade and expression of ER, PR and HER-2/neu on primary and metastatic tumours were recorded.
RESULTS: Hormone receptor status was compared between primary and metastatic tumours. Estrogen receptor positivity was observed in 28% primary tumours which were reduced to 25% in metastatic carcinoma. Progesterone receptors were positive in 28% primary tumours as compared to 22% in metastatic tumours. Her-2/neu protein over expression was noted in 44% primary and 45% metastatic breast tumours respectively. In case to case comparison ER, PR and HER-2/neu showed 91%, 88% and 95% concordance in primary and metastatic tumours respectively.
CONCLUSION: ER, PR and HER-2/neu biomarkers showed significant concordance between primary and metastatic breast carcinoma.
Publication (Name of Journal)
Journal of the Pakistan Medical Association
Recommended Citation
Azam, M.,
Qureshi, A.,
Mansoor, S.
(2009). Comparison of estrogen receptors, progesterone receptors and HER-2/neu expression between primary and metastatic breast carcinoma. Journal of the Pakistan Medical Association, 59(11), 736-40.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/31