Frequency of von willebrand disease and its types: Data from a tertiary care hospital of Karachi, Pakistan
Haematology/Oncology; Pathology and Laboratory Medicine
Introduction: von Willebrand disease is the most common inherited bleeding disorder. It is classified into 3 main types, type I and III are quantitative defects whereas type II is qualitative defect which is further sub-classified in to II-A, II-B, II-M, II-N. The aim of the present study is to see frequency and types of von Willebrand disease in a tertiary care hospital of Karachi, Pakistan.
Materials and methods: This retrospective cross-sectional study was conducted in the section of Hematology and Transfusion Medicine, Department of Pathology and Laboratory Medicine, the Aga Khan University hospital, Karachi, from May 2020 to April 2021 after the approval from Ethical Review Committee (2020-3537-10215). The data was analysed using SPSS version 20.
Results: A total of 552 samples for VWF Ag were received. vWD was identified in 47(8.5%) of the samples and 505 patients had no disease. Female to male ratio was 1.5:1. Median age was 11 years (ranges from 10 days to 70 years). Thirty (5.4%) of patients had Type I disease, 11 (2%) patients had type III, and out of 47 patients, 6 (1%) patients were diagnosed to have type II disease while 19 (3.4%) patients had low VWF Ag due to other causes.
Conclusion: In the current study, type I vWD was found to be the most common type, whereas other studies from Pakistan have commonly reported type III.
Journal of Haematology and Stem Cell Research
Lal, J. M.,
(2023). Frequency of von willebrand disease and its types: Data from a tertiary care hospital of Karachi, Pakistan. Journal of Haematology and Stem Cell Research, 2(2).
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/1437
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