Document Type
Article
Department
Pathology and Laboratory Medicine
Abstract
Background: The outcome of patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 is unknown and there are no specific treatment guidelines.
Methods: We describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022.
Results: Acute leukaemia and lymphoma were the most frequent HM (35.8% and 35.1%, respectively). Overall, 343 (76.2%) patients received treatment for HM, which was delayed for longer than one month since diagnosis in 57 (16.6%). An overall response rate was observed in 140 (40.8%) patients after the first line of treatment. After a median follow-up of 35 days, overall mortality was 177/450 (39.3%); 30-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004), either before and/or after COVID-19, or compared to patients receiving HM treatment at least after COVID-19 (15.2%, p < 0.001). Age, severe/critical COVID-19, ≥2 comorbidities, and lack of HM treatment were independent risk factors for mortality, whereas a lymphocyte count >500/mcl at COVID-19 onset was protective.
Conclusions: HM treatment should be delivered as soon as possible for patients with simultaneous diagnosis of COVID-19 and HM requiring immediate therapy.
Publication (Name of Journal)
Cancers
Recommended Citation
Cattaneo, C.,
Salmanton-García, J.,
Marchesi, F.,
El-Ashwah, S.,
Itri, F.,
Weinbergerová, B.,
Silva, M. G.,
Dargenio, M.,
Dávila-Valls, J.,
Ali, N.
(2022). Simultaneous onset of haematological malignancy and COVID: An epicovideha survey. Cancers, 14(22).
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/1427
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Included in
Critical Care Commons, Emergency Medicine Commons, Hematology Commons, Oncology Commons, Pathology Commons, Radiology Commons, Virus Diseases Commons
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