Document Type
Article
Department
Emergency Medicine; Pathology and Microbiology; Pathology and Laboratory Medicine
Abstract
Objective: To determine the use of pefloxacin as a surrogate marker to detect fluoroquinolone (ciprofloxacin) susceptibility against Salmonella enterica serotypes Typhi and Paratyphi A.
Methods: The prospective, descriptive cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, from September 2016 to March 2018, and comprised Salmonella Typhi and Paratyphi A isolates of blood cultures. Disk susceptibility tests and broth microdilution to test minimum inhibitory concentration were performed as per standard guidelines. Data was analysed using SPSS 21.
Results: Of the 138 isolates, 91(66%) were intermediate resistant to ciprofloxacin but were resistant to pefloxacin, 42(30%) were resistant to both ciprofloxacin and pefloxacin, and 5(4%) were susceptible to both ciprofloxacin and pefloxacin. Of the isolates that were intermediate resistant to ciprofloxacin, 85(93%) had minimum inhibitory concentration range0.12-0.5mg\L, while 6(7%) had MIC>1mg\L (p<0.0001).
Conclusions: Pefloxacin disk diffusion test was found to be reliable in detecting fluoroquinolone resistance among enteric fever causing Salmonella.
Publication ( Name of Journal)
JPMA. The Journal of the Pakistan Medical Association
Recommended Citation
Moin, S.,
Zeeshan, M.,
Laiq, S.,
Raheem, A.,
Zafar, A.
(2020). Use of pefloxacin as a surrogate marker to detect ciprofloxacin susceptibility in Salmonella enterica serotypes typhi and paratyphi A. JPMA. The Journal of the Pakistan Medical Association, 70(1), 96-99.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/1297
Included in
Microbiology Commons, Parasitic Diseases Commons, Pathological Conditions, Signs and Symptoms Commons, Pathology Commons