Case definition of chronic pulmonary aspergillosis in resource-constrained settings
Pulmonary and Critical Care; Pathology and Microbiology; Pathology and Laboratory Medicine
Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower- and middle-income countries as well as in resource-constrained settings.
Emerging Infectious Diseases
Denning, D. W.,
Page, I. D.,
Jude, C. M.,
(2018). Case definition of chronic pulmonary aspergillosis in resource-constrained settings. Emerging Infectious Diseases, 24(8), e171312.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/1287