Association of plasma leptin with coronary artery calcium (CAC) in adults

Document Type



Pathology and Laboratory Medicine


To determine the correlation between leptin and CAC in scores subjects without cardiovascular disease (CVD) risk.
Study Design:
Cross sectional study.
Place and Duration of Study:
Aga Khan University Hospital, from Mar 2014 to Jun 2015.
Material and Methods:
Total 128 subjects were included.The study was approved by ethical review committee. After informed consent a predesigned questionnaire was documented. Subjects without known cardiac disease history, coming for non-contrast CT scan for abdominal indications were included. Leptin levels were measured by Enzyme immunoassay. CAC scores were assessed on a 64 slice non-contrast CT scan. Data analyzed by SPSS version 20.
Total 128 subjects were included with mean age 42.82 ± 13.1 years and 78.1% (n=100) were males. Mean BMI and waist circumference was 27.1 ± 5.4 kg/m2 and 94.8 ± 9.0cm respectively. High median leptin levels were seen in 11.7% (n=15) of study subjects. Leptin levels were also significantly higher in female compared to male [12.5ng/ml (0.3-60.9) vs. 2.5ng/ml (0.1-50); p-value=0.001]. High CAC score was present in 15% (n=19) of study subjects.Statistically significant correlation of leptin was found with waist circumference, (r 0.50; p=0.001), positive correlation with BMI (r 0.51, p<0.05) with higher levels noted in obese subjects compared to overweight and normal BMI subjects [median 7.5ng/ml (0.3-60.9) vs. 3.3ng/ml (0.1-40) & 0.1 ng/ml (0.1-0.1)]; No correlation was found between CAC score and serum leptin levels (r 0.073; p=0.41).
Leptin levels are not correlated with CAC scores in subjects with low CVD risk. However, leptin was significantly higher in females and subjects with increased waist circumference


Pakistan Armed Forces Medical Journal