Establishment of reference intervals for alkaline phosphatase in Pakistani children using a data mining approach
Pathology and Laboratory Medicine
Objective: To establish reference intervals (RIs) for alkaline phosphatase (ALP) levels in Pakistani children using an indirect data mining approach.
Methods: ALP levels analyzed on a Siemens Advia 1800 analyzer using the International Federation of Clinical Chemistry's photometric method for both inpatients and outpatients aged 1 to 17 years between January 2013 and December 2017, including patients from intensive care units and specialty units, were retrieved. RIs were calculated using a previously validated indirect algorithm developed by the German Society of Clinical Chemistry and Laboratory Medicine's Working Group on Guide Limits.
Results: From a total of 108,845 results, after the exclusion of patients with multiple specimens, RIs were calculated for 24,628 males and 18,083 females with stratification into fine-grained age groups. These RIs demonstrate the complex age- and sex-related ALP dynamics occurring during physiological development.
Conclusion: The population-specific RIs serve to allow an accurate understanding of the fluctuations in analyte activity with increasing age and to support clinical decision making.
(2019). Establishment of reference intervals for alkaline phosphatase in Pakistani children using a data mining approach. Laboratory Medicine.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/1198