Solid pseudopapilllary neoplasm of the pancreas A clinicopathologic study of 25 cases from Pakistan and review of Literature

Document Type



Pathology and Laboratory Medicine


Our aim was to describe the clinicopathologic features of cases of solid pseudopapillary neoplasm (SPN) of the pancreas diagnosed in our section. We retrieved hematoxylin and eosin and immunohistochemistry slides of SPN of pancreas diagnosed between 2002 and 2014 and reviewed slides. A total of 25 cases were included in the study. All were females. Age ranged from 12 to 45 years with mean age of 24 years. Tail of pancreas was the commonest location (40%). Tumor size ranged from 2.5 to 20 cm (mean tumor size, 9.5 cm). Distal pancreatectomy and pancreaticoduodenectomy were the commonest types of surgical resections performed. Most cases were confined to the pancreas. However, 2 cases extended beyond the pancreas, and an additional case metastasized to the omentum and liver. Pseudopapillary architecture and hyaline globules were the commonest histologic features, seen in 100% and 84% of cases, respectively. Vimentin, cluster of differentiation 10, cluster of differentiation 56, and neuron-specific enolase were the most useful immunohistochemical stains. Of those cases, in which follow-up was available, almost all (except 1) patients were alive and well even several years after resection. In conclusion, SPN is a rare tumor in our practice. As in international studies, our study also showed predilection for young females and excellent prognosis after surgical resection.


Annals of Diagnostic Pathology