Seroprevalence of Hepatitis E and Helicobacter pylori in a low socioeconomic area of a metropolitan city in a developing country

Wasim Jafri, Aga Khan University
Javed Yakoob, Aga Khan University
Shahab Abid, Aga Khan University
Safia Awan, Aga Khan University
Shaheer Siddiqui, Aga Khan University
Fatima Jafri, Aga Khan University
Saeed Hamid, Aga Khan University
S Q. Nizami, Aga Khan University


This study aims to determine the prevalence of coinfection of H. pylori and hepatitis E virus (HEV) in the paediatric age group in an urban slum area of Karachi and identify risk factors associated with co-infection. Five hundred and forty children aged one to 15 years were investigated. Blood samples were collected and questionnaires completed on socio-demographic characteristics. Anti-H. pylori, HEV IgG and IgM antibodies were analysed by enzyme immunoassays (EIAs). Theseroprevalence of H. pylori antibody was 47.2%, while that of HEV IgG and IgM was 14.4% and 2.4%, respectively. 12.4% exhibited seroprevalence for both H. pylori and HEV (IgG). In 67 (26%) cases positive for H. pylori IgG, HEV IgG positivity was also seen (PH. pylori were also positive for HEV IgM (PH. pylori antibody-negative (PP=0.025). H. pylori was common in children who used a non-flush toilet system (PH. pyloriinfection were also exposed to the risk of HEV.