Hyper Immunoglobulin E syndrome also called Job's or Buckley Syndrome is a rare primary immunodeficiency disease characterized by elevated serum IgE levels (> 2000 IU/ml), recurrent infections and eosinophilia. Other features include coarse facies and non-immunologic abnormalities of the dentition, bones, vasculature and connective tissues. We are reporting a case of a twenty four years old male with coarse facies who presented with severe pallor and upper gastrointestinal bleeding. Investigations revealed markedly elevated serum IgE levels (11,800 IU/ml), severe anaemia, esophageoduodenal erosions, Helicobacter pylori (H. pylori) gastritis and oro-esophageal candidiasis.
Journal of Pakistan Medical Association
Tasneem, A. A.,
Hassan, S. M.,
Luck, N. H.,
(2013). Job's syndrome with an atypical presentation. Journal of Pakistan Medical Association, 63(11), 1427-1429.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_med_gastroenterol/204
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